Trim37 deficiency autophagy
WebApr 14, 2024 · In addition, PIK3CA (H1047R) did not alter CBFB deficiency-induced autophagy (Supplementary Fig. S6E). Similarly, CBFB had no effect on PIK3CA (H1047R) activity, as indicated by phospho-AKT levels (Supplementary Fig. S6E). Furthermore, IHC analyses showed MCF10A xenografts driven by CBFB KO and by both CBFB KO and … WebAug 1, 2024 · In summary, our results give clues to explain why TRIM37 deficiency in chondrocytes impacts bone growth. Modulating TRIM37 using miR-223 could be an approach to increase chondrogenesis. Graphical abstract. ... TRIM37 deficiency induces autophagy through deregulating the MTORC1-TFEB axis. Autophagy, 14 (2024), pp. 1574 …
Trim37 deficiency autophagy
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WebMar 30, 2024 · Autophagy plays an important role in TMT-treated Neuro-2a cells. Neurotoxicity of TMT in Neuro-2a cells was determined by CCK-8 assays. Treatment of cells with 2, 4, and 8 μM TMT for 24 h caused approximately 15%, 31%, and 44% reductions in cell viability, respectively (Figure 1A).Moreover, after exposure to TMT, we observed a reduced … WebDec 24, 2024 · In this review, we focus on TRIM37 in the normal cell and in pathological conditions, with an emphasis on the MULIBREY (MUscle-LIver-BRain-EYe) genetic disorder caused by TRIM37 mutations. TRIM37 is characterized by the presence of a RING domain, B-box motifs, and a coiled-coil region, and its C-terminal part includes the MATH domain …
WebApr 6, 2024 · Benefits of Autophagy. Autophagy has important effects that occur both within and outside of a cell. 1. Within the cell, autophagy can help: Decrease oxidative stress (damage to cells caused by unstable … WebJun 25, 2024 · Current studies show that the regulation of TRIM37 on disease may be related to autophagy, for example, TRIM37 depletion increases the basal autophagy flux …
http://cjbmb.bjmu.edu.cn/EN/10.13865/j.cnki.cjbmb.2024.03.1583 WebMar 13, 2024 · However, the underlying molecular mechanism of macrophage chaperone-mediated autophagy (CMA) in NASH remains unclear. ... By constructing myeloid-specific CMA deficiency mice, we evaluated the effects of deficient CMA of macrophages on monocyte recruitment, liver injury, steatosis and fibrosis in NASH mice.
Web(2024) Wang et al. Autophagy. TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a severe growth disorder with prenatal onset. Although TRIM37 depletion …
WebApr 12, 2024 · Interestingly, TRIM39 deficiency promoted the acidification of lysosomes as evidenced by an increased fluorescence intensity of the pH probe (Fig. S3d, e), suggesting … blue earth media productionsWebTRIM37 deficiency is plagued with numerous tumors. ... In this review, we summarized the advances in autophagy regulation by crosstalk between miRNA and E3 ubiquitin ligases or … blue earth meat marketWebThe enhanced autophagy depends on the inhibition of MTORC1 signaling and may serve as an alternative mechanism to survive the loss of TRIM37 functions. Our study unveils a positive role of TRIM37 in regulating the MTORC1-TFEB axis and provides mechanistic insights into the pathogenesis of mulibrey nanism, as well as potential therapeutic … freelance business attorney philadelphia paWebJun 27, 2024 · TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces … freelance book marketerWebAug 21, 2024 · TRIM37 depletion increases basal autophagic flux. To explore how cells respond to the stresses caused by the loss of TRIM37 functions, we examined the … freelance bookkeeping rates south africaWebAug 21, 2024 · TRIM37 gene mutations cause mulibrey (muscle-liver-brain-eye) nanism, a severe growth disorder with prenatal onset. Although TRIM37 depletion normally induces … freelance business introducer salary taiwanWebThe enhanced autophagy depends on the inhibition of MTORC1 signaling and may serve as an alternative mechanism to survive the loss of TRIM37 functions. Our study unveils a … blue earth mn county jail