Ot-551
WebFeb 2, 2024 · OT-551. The antioxidant eyedrop OT-551 (Othera Pharmaceuticals) was explored in a phase 2 trial (NCT00306488) after it demonstrated successful protection against retinal pigment epithelium (RPE) degeneration in preclinical models. Eleven individuals with bilateral geographic atrophy (GA) received topical 0.45% OT-551. WebNational Center for Biotechnology Information
Ot-551
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WebJan 27, 2014 · OT-551 is a compound similar to OT-647 with improved efficacy at prevention of phototoxic damage and inhibition of PUFA oxidation products in rats [46,47]. A small Phase II clinical trial of OT-551 in 10 patients with geographic atrophy (GA) arrested decreases in visual acuity when compared to the untreated control eye but did not alter … WebTopical OT-551 was administered to only one qualifying eye 4X daily for up to 2 years. Visits were scheduled at screening, baseline (BL), and at 1, 3, 6, 9, 12, 15, 18, 21 & 24 months. …
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WebJump Ahead, Little Falls. 27 East Main St, Little Falls, New Jersey 07424. (551) 247-1306. WebOT-551 is the first eye drop to ever be tested in a clinical trial as a treatment for dry AMD. The analysis of drug safety and effectiveness for the entire study population and in …
WebNov 7, 2008 · An antioxidant eye drop (OT-551, Othera) is being investigated to treat geographic atrophy in dry age-related macular degeneration (AMD), said Paul Sternberg, MD, from the Vanderbilt Eye Institute, Vanderbilt University School of Medicine, Nashville, TN.
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