Mafb and osteoclast
WebJun 20, 2024 · The quantity and activation state of adipose tissue macrophages (ATMs) impact the development of obesity-induced metabolic diseases. Appetite-controlling hormones play key roles in obesity;... WebBecause miR-338-3p is crucial for osteoclastic differentiation via targeting of the transcription factor MafB, inhibition of this miRNA represents a potential strategy for …
Mafb and osteoclast
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WebSep 1, 2024 · Activated NFATc1 stimulates Nfatc1 self-amplification and expression of osteoclast-specific genes, and Blimp1 represses anti-osteoclastogenic genes such as Irf8 … WebOct 12, 2014 · Mechanistic studies revealed that WNT16 is osteoblast derived and inhibits human and mouse osteoclastogenesis both directly by acting on osteoclast progenitors …
WebFeb 2, 2015 · Mafb expression is diminished in RXR-KO osteoclast progenitors. To determine the molecular mechanism underlying the abnormal RXR-KO osteoclast phenotype, we … WebJan 1, 2024 · In summary, the possible reasons why only RANKL can function as the master regulator of osteoclast differentiation in the face of other cytokines are as follows: (1) …
WebApr 15, 2007 · Herein, we present evidence that MafB has dual roles as a repressor of osteoclastogenesis as well as an inducer of macrophage differentiation, suggesting that … WebMar 23, 2024 · In this study, we generated zebrafish MAFB homolog mafbb mutant utilizing CRISPR/Cas9 technology. Mafbb deficient zebrafish demonstrated enhanced osteoclast …
WebApr 10, 2024 · (a) Confocal microscopy of RAW 264.7 cells treated without (vehicle only) or with 300 nM or 3 μM C3larvinA‐DyLight‐488 and incubated for 5 h at 37°C prior to being fixed and stained with...
Webinto osteoclasts in vitro, resorb bone, and have an equivalent expression of main osteoclast markers as monocyte-derived … tti pool heaterWebEvaluation of osteoclast progenitor cells revealed that RXR homodimers directly target and bind to the Mafb promoter, and this interaction is required for proper osteoclast proliferation, differentiation, and activity. Pharmacological activation of RXRs inhibited osteoclast differentiation due to the formation of RXR/liver X receptor (LXR ... tti psychometric tests harvardWebMar 21, 2024 · GeneCards Summary for MAFB Gene. MAFB (MAF BZIP Transcription Factor B) is a Protein Coding gene. Diseases associated with MAFB include Multicentric … ttip meaningWebMar 23, 2024 · It is known that MafB inhibits the expression of NFATc1 and the osteoclast-associated receptor (OSCAR) during RANKL-mediated osteoclastogenesis, and thereby … phoenix eagle boardWebAbstract Pulmonary fibrosis (PF) is a heterogeneous disease with a poor prognosis. Therefore, identifying additional therapeutic modalities is required to improve outcome. However, the lack of biom... An Integrative Multiomics Framework for Identification of Therapeutic Targets in Pulmonary Fibrosis - Arif - Advanced Science - Wiley Online Library ttipp model for teachersWebNov 11, 2024 · Osteoclast differentiation is initiated by receptor activator of nuclear factor-κB ligand (RANKL) and macrophage-colony-stimulating factor (M-CSF), which are engaged by various cells, including stromal cells, osteoblasts, and osteocytes [ 5, 6 ]. ttiq very high caseloadWebAmong these, we identified MAFB [ 44] and WNT1 [ 45, 46] which have been reported to be pivotal modulators of bone remodeling through the regulation of osteoclasts [ 44] and osteoblasts [ 47] differentiation, respectively, thus suggesting a potential role for miR-148a in the regulation of bone resorption and deposition in physiologic conditions … phoenix dually simulators