Fixed dose rasburicase
WebRasburicase prophylactic dosing The licensed dose is 0.2mg/kg/day IV for up to 7 days (Sanofi, 2024), however a meta-analysis reviewing the effectiveness of a single fixed … WebRasburicase is a recombinant urate oxidase enzyme approved for use in tumor lysis syndrome (TLS) and it acts by reducing serum uric acid levels. Using rasburicase at the recommended dose of...
Fixed dose rasburicase
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WebFeb 18, 2014 · The median uric acid level reduction 24 h post rasburicase dose 1.5 mg, 3 mg, 4.5 mg, and 6 mg were 5.5, 5.8, 3.8, and 10.05 mg/dL, respectively. There was no … WebApr 15, 2013 · Rasburicase is a recombinant urate-oxidase enzyme approved by the Food and Drug Administration in 2002 for the treatment of hyperuricemia in patients receiving …
Webwww.ncbi.nlm.nih.gov WebMar 1, 2011 · The current recommended dose is 0.2 mg/kg/day administered intravenously with the first dose given prior to chemotherapy. ... Shanholtz CB, Thompson JL. Fixed-dose rasburicase 6 mg for hyperuricemia and tumor lysis syndrome in high-risk cancer patients. Ann Pharmacother. 2010;44:1529-1537. Uric acid as a weak organic acid (pka 5.8) is …
WebThe only patient who did not respond to the single 6-mg rasburicase dose was a morbidly obese man (259 kg, body mass index 87 kg/m2) who subsequently responded to an additional dose of rasburicase 12 mg. These results warrant further investigation of a single 6-mg dose of rasburicase in adults with TLS or at high-risk for developing TLS. WebRasburicase dosing was at the discretion of the treating clinician, and the initial dose ranged from 1.5 to 16.5 mg. Nine patients had uric acid levels above the normal range …
WebJun 13, 2005 · Rasburicase is a recombinant form of urate-oxidase enzyme used to treat hyperuricemia following chemotherapy for leukemias and non-Hodgkin's lymphoma. …
WebThe labeled dose is 0.2 mg/kg/day administered intravenously over 30 minutes for up to 5 days. Our institutional adult guidelines recommend rasburicase 6 mg for uric acid levels … tnc chickenWebJun 1, 2011 · It is concluded that a single 3-mg dose of rasburicase, used with close monitoring, is sufficient to treat most adults with uric acid levels up to 12 mg/dL, and continues to decline beyond 24 h in most patients without additional treatment. Rasburicase was administered at a fixed dose of 3 mg to treat 287 episodes of elevated serum uric … tncc historic triangle campusWebDec 3, 2015 · Based on the average wholesale price of $815 for one 1.5 mg vial of rasburicase, the single 3 mg dose was associated with … tncc helpful hintsWebNov 25, 2016 · We conducted separate analyses for fixed single doses ranging from 1·5 to 7·5 mg and weight-based single doses. Outcomes of the same dosing groups were pooled together and then compared with data extracted from the other dosage groups. ... Single-dose rasburicase is efficient in lowering UA level and in preventing and treating children … tncc homepageWeb12. Liu CY1, Sims-McCallum RP et al. A single dose of rasburicase is sufficient for the treatment of hyperuricemia in patients receiving chemotherapy. Leuk Res. 2005 Apr;29(4):463-5.Epub 2004 Dec8. 13. Trifilio S, Gordon L, Singhal S et al. Reduced-dose rasburicase (recombinant xanthine oxidase) in adult cancer patients with hyperuricemia. tnc chemicals philsWebOur results demonstrate that a single fixed dose of rasburicase 3 mg, repeated if required, should be the standard regimen in the management of TLS. Recent studies and published guidelines have shown cumulative … tncc historic triangleWebRasburicase Elitek Antihyperuricemic agent Injection: 1.5, 7.5 mg; contains mannitol and L-alanine Hyperuricemia (all ages): 0.1–0.2 mg/kg/dose (rounded down to the nearest whole 1.5 mg multiple) IV over 30 min × 1. Patients generally respond to one dose but if needed dose may be repeated Q 24 hr for up to four additional doses. tnc chestnut mountain