WebJun 12, 1998 · Chloral hydrate is a hepatocarcinogen in mice but not rats. To examine this species-related difference, male and female B6C3F1 mice and Fischer (F344) rats were treated by gavage with 1 or 12 doses of chloral hydrate, and concentrations of the drug and its metabolites were determined in plasma at 0.25, 7, 3, 6, and 24 h and 2, 4, 8, and 16 d … WebThird, we admit that we neglect the potential problem of using chloral hydrate for euthanasia of rats. Chloral hydrate is a traditional anesthetic in animal experiments, and …

Chloral Hydrate Is Not Acceptable for Anesthesia or

WebAll mice were intraperitoneally injected (10 mL·kg −1) with a 4% chloral hydrate solution for anesthesia. For ALI model group, the mice were instilled with 50 μL of LPS solution at a concentration of 1.5 mg·mL −1. (Dose was 3 mg·kg −1); the mice in the blank control group were instilled with the same volume of normal saline, and the ... WebChloral hydrate has been used in human and veterinary medicine as a sedative and hypnotic drug since the mid-19th century. Chloral hydrate's effects are primarily caused by its active metabolite trichloroethanol. Chloral hydrate is primarily a hypnotic and has little or no analgesic effect. In candidates for surgery, it is a satisfactory ... rich rivera nj

Anesthesia for euthanasia influences mRNA expression in healthy mice ...

WebDec 1, 2013 · To explore effect of different anesthesia methods and different anesthetics on erythrocyte immune function in mice. Methods. The mice were anesthetized by … WebAll surgery was performed under chloral hydrate anesthesia, and all efforts were made to minimize suffering. ... All mice were sacrificed under chloral hydrate anesthesia at day 21 after the first injection. Tumor nodules in the abdominal cavity were collected and weighed; mice weight and ascites were also evaluated in all groups. rich rojeski st george utah